Our new review in Current Opinion in Biotechnology

This review highlights the recent advances of Pseudomonas species as versatile cell factories for the circular bioeconomy. Naturally robust, these bacteria already possess broad metabolic capabilities yet can be further enhanced on their substrate scope. The review focuses on three key nonconventional feedstocks: lignocellulosic residues, where engineered Pseudomonas can co-utilize cellulose and hemicellulose-derived sugars, and aromatic lignin monomers; plastic waste, demonstrating how combined chemical deconstruction and biological funneling can upgrade polymer-derived building blocks into valuable products; and C1 substrates, showcasing early but promising progress in enabling Pseudomonas to grow on formate or methanol through newly introduced one-carbon fixation pathways. The review underscores how expanding substrate scope, together with improved strain robustness, will be critical for scalable, eco-friendly bioprocesses that upcycle waste streams into fuels, chemicals, and valuable materials.
You can find the article here: https://doi.org/10.1016/j.copbio.2025.103270