Publications
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarström Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. Nature, 2021, https://doi.org/10.1038/s41586-021-03461-y
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein. Bianchini F, Crivelli V, Abernathy ME, Guerra C, Palus M, Muri J, Marcotte H, Piralla A, Pedotti M, De Gasparo R, Simonelli L, Matkovic M, Toscano C, Biggiogero M, Calvaruso V, Svoboda P, Cervantes Rincón T, Fava T, Podešvová L, Shanbhag AA, Celoria A, Sgrignani J, Stefanik M, Hönig V, Pranclova V, Michalcikova T, Prochazka J, Guerrini G, Mehn D, Ciabattini A, Abolhassani H, Jarrossay D, Uguccioni M, Medaglini D, Pan-Hammarström Q, Calzolai L, Fernandez D, Baldanti F, Franzetti-Pellanda A, Garzoni C, Sedlacek R, Ruzek D, Varani L, Cavalli A, Barnes CO, Robbiani DF. Science Immunology, 2023, https://www.science.org/doi/10.1126/sciimmunol.ade0958
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Agudelo M, Palus M, Keeffe JR, Bianchini F, Svoboda P, Salát J, Peace A, Gazumyan A, Cipolla M, Kapoor T, Guidetti F, Yao KH, Elsterová J, Teislerová D, Chrdle A, Hönig V, Oliveira T, West AP, Lee YE, Rice CM, MacDonald MR, Bjorkman PJ, Růžek D, Robbiani DF, Nussenzweig MC. Journal of Experimental Medicine, 2021, https://doi.org/10.1084/jem.20210236
Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. Füzik T, Formanová P, Růžek D, Yoshii K, Niedrig M, Plevka P. Nature Communication, 2018, https://doi.org/10.1038/s41467-018-02882-0
Omsk haemorrhagic fever. Růžek D, Yakimenko VV, Karan LS, Tkachev SE. Lancet, 2010, https://doi.org/10.1016/S0140-6736(10)61120-8
Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology. Holoubek J, Bednářová K, Haviernik J, Huvarová I, Dvořáková Z, Černý J, Outlá M, Salát J, Konkol'ová E, Boura E, Růžek D, Vorlíčková M, Eyer L, Renčiuk D. Nucleic Acids Research, 2022, https://doi.org/10.1093/nar/gkac225
(7) Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles - A recombinant vaccine candidate. Zimna M, Brzuska G, Salát J, Růžek D, Krol E. Antiviral Research,2024. https://doi.org/10.1016/j.antiviral.2024.105941
(6) Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cervantes Rincón T, Kapoor T, Keeffe JR, Simonelli L, Hoffmann HH, Agudelo M, Jurado A, Peace A, Lee YE, Gazumyan A, Guidetti F, Cantergiani J, Cena B, Bianchini F, Tamagnini E, Moro SG, Svoboda P, Costa F, Reis MG, Ko AI, Fallon BA, Avila-Rios S, Reyes-Téran G, Rice CM, Nussenzweig MC, Bjorkman PJ, Ruzek D, Varani L, MacDonald MR, Robbiani DF. Cell Reports, 2024. https://doi.org/10.1016/j.celrep.2024.114298
2023 Publications
(19) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Holoubek J, Salát J, Kotouček J, Kastl T, Vancová M, Huvarová I, Bednář P, Bednářová K, Růžek D, Renčiuk D, Eyer L. Antiviral Research, 2023. https://doi.org/10.1016/j.antiviral.2023.105767
(18) Alkyl derivatives of perylene photosensitizing antivirals: towards understanding the influence of lipophilicity Mikhnovets IE, Holoubek J, Panina IS, Kotouček J, Gvozdev DA, Chumakov SP, Krasilnikov MS, Zhitlov MY, Gulyak EL, Chistov AA, Nikitin TD, Korshun VA, Efremov RG, Alferova VA, Růžek D, Eyer L, Ustinov AV. International Journal of Molecular Sciences, 2023. https://doi.org/10.3390/ijms242216483
(17) Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis Fortova A, Barkhash A.V, Pychova M, Krbkova L, Palus M, Salat J and Ruzek D. Journal of NeuroVirology, 2023. https://doi.org/10.1007/s13365-023-01182-8
(16) Vaccination against tick-borne encephalitis elicits a detectable NS1 IgG antibody response Ackermann-Gäumann R., Brêchet A, Smetana J, Salát J, Lienhard R, Croxatto A, Polcarová P, Chlíbek R and Růžek D. Journal of Virological Methods, 2023. https://doi.org/10.1016/j.jviromet.2023.114831
(15) A Combination of Two Resistance Mechanisms Is Critical for Tick-Borne Encephalitis Virus Escape of Broadly Neutralizing Human Antibody Svoboda P, Haviernik J, Bednar P, Matkovic M, Cervantes R T, Keeffe J, Palus M, Salat J, Agudelo M, Nussenzweig M C, Cavalli A, Robbiani D F, and Ruzek D. Cell Reports, 2023. https://doi.org/10.1016/j.celrep.2023.113149
(14) Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs Salát J, Hunady M, Svoboda P, Strelcova L, Strakova P, Fortova A, Palus M, Ruzek D. Vaccine, 2023. https://doi.org/10.1016/j.vaccine.2023.09.019
(13) Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture
Chiffi G, Grandgirard D, Leib SL, Chrdle A, Růžek D. Reviews in Medical Virology, 2023. https://doi.org/10.1002/rmv.2470
(12) Antiviral Activity Of Singlet Oxygen-Photogenerating Perylene Compounds Against Sars-Cov-2: Interaction With The Viral Envelope And Photodynamic Virion Inactivation Straková P., P. Bednář, J. Kotouček, J. Holoubek, A. Fořtová, P. Svoboda, M. Štefánik, I. Huvarová, P. Šimečková, J. Mašek, D. A. Gvozdev, I. E Mikhnovets, A. A. Chistov, T. D. Nikitin, M. S. Krasilnikov, A. V. Ustinov, V. A. Alferova, V. A. Korshun, D. Růžek and L. Eyer. Virus Research, 2023. https://doi.org/10.1016/j.virusres.2023.199158
(11) Development Of Recombinant West Nile Virus Expressing Mcherry Reporter Protein Kobayashi, S., Y. Fukuda, K Yoshii, P Thammahakin, K Maezono, L. Eyer, D. Růžek and H Kariwa. Journal Of Virological Methods, 2023. https://doi.org/10.1016/j.jviromet.2023.114744
(10) Editorial For The Special Issue: "Tick-Borne Encephalitis" Růžek D. Microorganisms, 2023. https://doi.org/10.3390/microorganisms11040934
(9) First Expert Elicitation Of Knowledge On Possible Drivers Of Observed Increasing Human Cases Of Tick-Borne Encephalitis In Europe Saegerman C., M. F. Humblet, M. Leandri, G. Gonzalez, P. Heyman, H. Sprong, M. L’hostis, S. Moutailler, S. I. Bonnet, N. Haddad, N. Boulanger, S. L. Leib, T. Hoch, E. Thiry, L. Bournez, J. Kerlik, A. Velay, S. Jore, E. Jourdain, E. Gilot-Fromont, K. Brugger, J. Geller, M. Studahl, N. Knap, T. Avšič-Županc, D. Růžek, T. P. Zomer, R. Bødker, T. F. H. Berger, S. Martin-Latil, N. De Regge, A. Raffetin, S. A. Lacour, M. Klein, T. Lernout, E. Quillery, Z. Hubálek, F. Ruiz-Fons, A. Estrada-Peña, P. Fravalo, P. Kooh, F. Etore, C. M. Gossner and B. Purse. Viruses, 2023. https://doi.org/10.3390/v15030791
(8) In silico and in vitro evaluation of imatinib as an inhibitor for SARS-CoV-2. Mulgaonkar N, Wang H, Mallawarachchi S, Růžek D, Martina B, Fernando S. Journal of Biomolecular Structure and Dynamics, 2023. https://doi.org/10.1080/07391102.2022.2045221
(7) Functional Characterization And Immunogenicity Of A Novel Vaccine Candidate Against Tick-Borne Encephalitis Virus Based On Leishmania-Derived Virus-Like Particles Zimna M., G. Brzuska, J. Salát, P. Svoboda, K. Baranska, B. Szewczyk, D. Růžek and E. Krol. Antiviral Research, 2023. https://doi.org/10.1016/j.antiviral.2022.105511
(6) Human Neutralizing Antibodies To Cold Linear Epitopes And Subdomain 1 Of The Sars-Cov-2 Spike Glycoprotein Bianchini F., V. Crivelli, M. E. Abernathy, C. Guerra, M. Palus, J. Muri, H. Marcotte, A. Piralla, M. Pedotti, R. De Gasparo, L. Simonelli, M. Matkovic, C. Toscano, M. Biggiogero, V. Calvaruso, P. Svoboda, T. C. Rincón, T. Fava, L. Podešvová, A. A. Shanbhag, A. Celoria, J. Sgrignani, M. Stefanik, V. Hönig, V. Pranclova, T. Michalcikova, J. Prochazka, G. Guerrini, D. Mehn, A. Ciabattini, H. Abolhassani, D. Jarrossay, M. Uguccioni, D. Medaglini, Q. Pan-Hammarström, L. Calzolai, D. Fernandez, F. Baldanti, A. Franzetti-Pellanda, C. Garzoni, R. Sedlacek, D. Růžek, L. Varani, A. Cavalli, C. O. Barnes and D. F. Robbiani. Science Immunology, 2023. https://www.science.org/doi/10.1126/sciimmunol.ade0958
(5) In-Depth Temporal Transcriptome Profiling Of Monkeypox And Host Cells Using Nanopore Sequencing Kakuk B., Á. Dörmő, Z. Csabai, G. Kemenesi, J. Holoubek, D. Růžek, I. Prazsák, V. É. Dani, B. Dénes, G. Torma, F. Jakab, G. E. Tóth, F. V. Földes, B. Zana, Z. Lanszki, Á. Harangozó, Á. Fülöp, G. Gulyás, M. Mizik, A. A. Kiss, D. Tombácz and Z. Boldogkői. Scientific Data, 2023. https://doi.org/10.1038/s41597-023-02149-4
(4) New Directions In The Experimental Therapy Of Tick-Borne Encephalitis Eyer L., K. Seley-Radtke and D. Růžek. Antiviral Research, 2023. https://doi.org/10.1016/j.antiviral.2022.105504
(3) Radiopaque Nanorobots As Magnetically Navigable Contrast Agents For Localized In Vivo Imaging Of The Gastrointestinal Tract Oral C. M., M. Ussia, M. Urso, J. Salát, A. Novobilsky, M. Stefanik, D. Růžek and M. Pumera. Advanced Healthcare Materials, 2023. https://doi.org/10.1002/adhm.202202682
(2) Serum Matrix Metalloproteinase-9 (Mmp-9) As A Biomarker In Paediatric And Adult Tick-Borne Encephalitis Patients Fořtová A., V. Hönig, J. Salát, M. Palus, M. Pýchová, L. Krbková, A. V. Barkhash, M. F. Kriha, A. Chrdle, M. Lipoldova and D. Růžek. Virus Research, 2023. https://doi.org/10.1016/j.virusres.2022.199020
(1) The Influence Of Adjuvant Type On The Immunogenicity Of Rbd/N Cocktail Antigens As A Vaccine Candidate Against Sars-Cov-2 Virus Brzuska G., M. Zimna, K. Baranska, B. Szewczyk, P. Strakova, D. Růžek and E. Krol. Microbiol Spectrum, 2023. https://doi.org/10.1128/spectrum.02564-22
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